Prion protein and cancers
نویسندگان
چکیده
منابع مشابه
Prion protein and cancers.
The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we r...
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The cellular prion protein (PrP(C)) has been widely investigated ever since its conformational isoform, the prion (or PrP(Sc)), was identified as the etiological agent of prion disorders. The high homology shared by the PrP(C)-encoding gene among mammals, its high turnover rate and expression in every tissue strongly suggest that PrP(C) may possess key physiological functions. Therefore, defini...
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The chemical nature of prions and the mechanism by which they propagate are now reasonably well understood. In contrast, much less is known about the identity of the toxic prion protein (PrP) species that are responsible for neuronal death, and the cellular pathways that these forms activate. In addition, the normal, physiological function of cellular PrP (PrP(C)) has remained mysterious, hampe...
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1 7 6 7 jci.org Volume 125 Number 5 May 2015 Introduction Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder of motor neurons that begins focally and spreads, leading to weakness of limb, respiratory, and bulbar muscles. Immediately preceding death, there is a near total loss of limb and respiratory function, as well as a loss of the ability to chew, swallow, and speak. ALS is...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2014
ISSN: 1745-7270,1672-9145
DOI: 10.1093/abbs/gmu019